An efficient magnetothermal actuation setup for fast heating/cooling cycles or long-term induction heating of different magnetic nanoparticle classes

Abstract Alternating magnetic fields (AMFs) in the ~100 kHz frequency regime cause nanoparticles (MNPs) to dissipate heat their nanoscale environment. This mechanism is beneficial for a variety of applications biomedicine and nanotechnology, such as localized heating cancer tissue, actuation drug release, or inducing conformational changes molecules. However, engineering electromagnetic resonant circuits which generate efficiently MNPs over long time scales, remains challenge. In addition, many require fast heating/cooling cycles ΔT = 5-10 °C switch sample between different states. Here, we present home-built magnetothermal setup maximized its efficiency deliver stable AMFs well enable MNP samples. The satisfies various demands, an elaborate cooling system control circuit components due inductive losses. Fast remote (up ±15 °C/min) long-term induction were monitored via contact-free thermal image recording at sub-mm resolution. Next characterizing improved hyperthermia setup, demonstrate applicability types MNPs: ‘Nanoflower’-shaped multicore iron oxide nanoparticles, core shell magnetite MNPs, Magnetosomes from magnetotactic bacteria (Magnetospirillum gryphiswaldense). are directly compared structure, surface charge, properties response. Our work provides practical guidelines AMF monitoring biomedical nano-/biotechnological applications.